纯度:98% by TLC,;NMR (Conforms)
分子式:C38H44O8
分子量:628.75
溶剂:DMSO (45 mg/ml) Ethanol (50 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):Survivin inhibitor
Function / Pharmacology:Induces apoptosis in a variety of cell lines acting as an antagonist of Bcl-2 family proteins (IC50 < 1 μM)1, however additional targets may contribute to its cytotoxicity. It suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition.2 Potentiates the chemosensitivity of cancer cells to other agents.3 Down-regulates surviving, reversing docetaxel resistance in cancer cells.4