纯度:>90% by TLC [1:9 CH3OH:CH2Cl2, Rf = 0.54] remainder is P-1, P-2 and P-4.;NMR (Conforms)
分子式:C32H43ClN2O9
分子量:635.16
溶剂:DMSO (50 mg/ml) Ethanol (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Microtubule depolymerizer
Function / Pharmacology:Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin1,2. Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity against various human tumor cell lines2,3. Maytansine and its analogs cause extensive disassembly of microtubules and totally prevent tubulin spiralization4.