纯度:98% by HPLC, Elemental Analysis (Conforms)
分子式:Cl2H4N2Pt
分子量:300.05
溶剂:Water (2.5 mg/ml with warming) or DMF; will dissolve in DMSO, but DMSO inactivates cytotoxicity5
性状:Yellow solid
存储:RT
Activity (short version):Anticancer agent
Function / Pharmacology:Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma cells.2 Inhibits expression of X-linked inhibitor of apoptosis protein (XIAP) in human LNCaP cells.3 Numerous mechanisms inhibit propagation of cisplatin-induced DNA damage to signal apoptosis resulting in resistance.4 Clinically useful anticancer agent.