纯度:98% by HPLC;NMR (Conforms)
分子式:C16H23N3O4 ? CH3SO3H
分子量:417.48
溶剂:DMSO (50 mg/ml) Water (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Serine protease inhibitor
Function / Pharmacology:A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis.1 Reduces weight gain and improves metabol-ism in obese rodent models.2 In clinical use (in Japan) for pancreatitis.3 Inhibits influenza virus replication in human tracheal epithelial cells.4 Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming.5