纯度:98% by HPLC,;NMR (Conforms)
分子式:C15H8N2O2
分子量:248.24
溶剂:DMSO (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Immunomodulator; IDO2 inhibitor
Function / Pharmacology:A indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1 Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling.2 Displays antiinflammatory activity targeting IL-17.3 Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM.4 Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.5