纯度:98% by TLC,;NMR (Conforms)
分子式:C16H25N2O5S Na
分子量:380.43
溶剂:DMSO (3 mg/ml) Water (35 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Protease inhibitor
Function / Pharmacology:Dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1 Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2 Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3 Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4