纯度:98% by HPLC,;NMR (Conforms)
分子式:C14H18N2O
分子量:230.31
溶剂:DMSO (25 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:RT
Activity (short version):Neuroinflammation inhibitor (PDE pan-inhibitor)
Function / Pharmacology:Phosphodiesterase inhibitor with some selectivity for PDE4 and 5. (IC50s= 53, 35, 48,12 and10 μM for PDE 1a, 2, 3, 4 and 5 respectively1). Acts as a cerebral vasodilator by selectively inducing a cGMP-independent relaxation of the intracranial vertebrobasilar artery.2 Attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma via PKA signaling.3 A glial cell activation inhibitor.4 Enhances morphine analgesia and attenuates tolerance and withdrawaI.5 Orally active and crosses the blood-brain barrier.5