纯度:>98% by HPLC,;NMR (Conforms)
分子式:C23H22O6
分子量:394.42
溶剂:DMSO (50 mg/ml)
性状:Off-white solid
存储:RT
Activity (short version):Mitochondrial Complex I Inhibitor
Function / Pharmacology:Rotenone (83-79-4), the most common member of the rotenoid natural product family, inhibits complex I of the mitochondrial electron transport chain (IC50 = 1.7 – 2.2 μM).1 Also inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM).2 May be used to induce Parkinsonism in animal models.3,4 Inhibits autophagy by blocking lysosomal degradation of autophagic vacuoles.5