纯度:98% by TLC,;NMR (Conforms)
分子式:C3H6N2O2
分子量:102.09
溶剂:DMSO (20 mg/ml) with warming, Water (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Sphingolipid biosynthesis inhibitor
Function / Pharmacology:L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4