纯度:>98% TLC/GC NMR (Conforms)
分子式:C18H18O2
分子量:266.34
溶剂:DMSO (50 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):SIRT3 activator
Function / Pharmacology:Honokiol is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4