纯度:98% by TLC [5% methanol in methylene chloride + 0.5% HOAc; Rf = 0.21]
分子式:C19H17N3O
分子量:303.36
溶剂:DMSO (5 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):TRPV1 agonist, antiinflamatory, antiangiogenic
Function / Pharmacology:Evodiamine is a quinolone alkaloid isolated from Evodia rutaecarpa.1 Evodia Rutaecarpa is a very popular herb used in traditional chinese medicine to treat a variety of ailments. It has been shown to elicit a variety of biological effects including induction of apoptosis, inhibiting cancer cell proliferation, promoting cell cycle arrest in G2/M, inhibiting invasion and metastasis of cancer cells, inhibiting angiogenesis, induction of oxidative stress and subsequent apoptosis and inhibition of NF-κB.2 It also functions as an agonist of TRPV1 (EC50 = 1.03 μM)3 and acts as an anti-inflammatory agent4.