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Halofuginone HBr
- 英文名称:Halofuginone HBr
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10656
- cas:64924-67-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10656 |
用途 | 科研检测 |
英文名称 | Halofuginone HBr |
包装规格 | 1MG |
CAS编号 | 64924-67-0 |
别名 | Halofuginone HBr |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by TLC;NMR (Conforms)
分子式:C16H17BrClN3O3 ? HBr
分子量:495.6
溶剂:DMSO (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Prolyl-tRNA synthase inhibitor
Function / Pharmacology:Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation.2 Blocks fibrosis, angiogenesis, and tumor progression.2,3 Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry.6
分子式:C16H17BrClN3O3 ? HBr
分子量:495.6
溶剂:DMSO (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Prolyl-tRNA synthase inhibitor
Function / Pharmacology:Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation.2 Blocks fibrosis, angiogenesis, and tumor progression.2,3 Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry.6