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Halofuginone HBr
  • 英文名称:Halofuginone HBr
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10656
  • cas:64924-67-0
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10656
用途 科研检测
英文名称 Halofuginone HBr
包装规格 1MG
CAS编号 64924-67-0
别名 Halofuginone HBr
纯度 98+%
分子式
是否进口
纯度:>98% by TLC;NMR (Conforms)
分子式:C16H17BrClN3O3 ? HBr
分子量:495.6
溶剂:DMSO (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Prolyl-tRNA synthase inhibitor
Function / Pharmacology:Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation.2 Blocks fibrosis, angiogenesis, and tumor progression.2,3 Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry.6
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