纯度:98% by TLC;NMR (Conforms)
分子式:C15H14O3
分子量:242.27
溶剂:DMSO (35 mg/ml) Ethanol (15 mg/ml
性状:Orange solid
存储:-20°C
Activity (short version):Topoisomerase I inhibitor
Function / Pharmacology:A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of ?-lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NF?B.5