纯度:98% by TLC,;NMR (Conforms)
分子式:C14H11N3O3S
分子量:301.32
溶剂:DMSO (10 mg/ml)
性状:White or off-white solid
存储:RT
Activity (short version):Microtubule inhibitor
Function / Pharmacology:Nocodazole is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex.1,2 Arrests cell cycle at G2/M phase. Stimulates the intrinsic GTPase activity of tubulin.3 Nocodazole activates the JNK/SAPK signaling pathway and induces apoptosis in a variety of cell lines.4 Increases Cas9-mediated editing frequencies5 and increased CRISPR-mediated HDR DNA repair6. Cell permeable.