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EHNA HCl
  • 英文名称:EHNA HCl
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10683
  • cas:51350-19-7
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10683
用途 科研检测
英文名称 EHNA HCl
包装规格 1MG
CAS编号 51350-19-7
别名 EHNA HCl
纯度 98+%
分子式
是否进口
纯度:98% by HPLC NMR (Confirms)
分子式:C14H28N5O ? HCl
分子量:318.87
溶剂:Water (25 mg/ml)
性状:Pale yellow or off-white solid
存储:RT
Activity (short version):PDE2 inhibitor
Function / Pharmacology:EHNA inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 μM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 μM).1,2 It also inhibits adenosine deaminase (ADA), IC50 = 1.2 and 1.5 μM in human RBCs and astrocytoma cells, respectively3, which may be responsible for its ability to induce apoptosis in malignant pleural mesothelioma cell lines4. Because it blocks breakdown of adenosine to inosine and hypoxanthine, EHNA prevents formation of free radical substrates, protecting against cardiac reperfusion-mediated injury.5 It inhibits differentiation and maintains expression of pluripotency markers in hESCs, but not through inhibition of PDEs or ADA.6
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