纯度:>98% by HPLC,;NMR (Conforms)
分子式:C13H18ClNO·HCl
分子量:276.2
溶剂:DMSO (40 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Monoamine transporter inhibitor
Function / Pharmacology:Clinically useful antidepressant that inhibits monoamine transporters DAT, NET, and SERT (Kis for dopamine uptake = 2.8, 1.4, 45 μM).1 Also acts as a noncompetitive antagonist at nicotinic acetylcholine receptors (AChRs).2 At higher concentrations (50 μM), stimulates pro-inflammatory cytokines and TLR2/TLR4 and JAK2/STAT3 in human peripheral blood mononuclear cells (PBMCs).3