纯度:98% by TLC,;NMR (Conforms)
分子式:C9H14N2O5
分子量:230.22
溶剂:Water (10 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Immunomodulator (S1P lyase inhibition)
Function / Pharmacology:THI was identified as a biologically active impurity in caramel food coloring.1 It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase.2 It disrupts lymphocyte egress from lymphoid tissue by interfering with S1P gradients.3,4 The novel immunomodulatory activity of THI and its biochemical mechanism may represent a new target for the development of new generation of immunosuppressants.5