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Rocaglamide
  • 英文名称:Rocaglamide
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10705
  • cas:84573-16-0
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-16
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10705
用途 科研检测
英文名称 Rocaglamide
包装规格 1MG
CAS编号 84573-16-0
别名 Rocaglamide
纯度 98+%
分子式
是否进口
纯度:97% by HPLC
分子式:C29H31NO7
分子量:505.57
溶剂:DMSO Ethanol
性状:White solid - presented as thin film on glass vial
存储:-20°C
Activity (short version):TNF-α inhibitor
Function / Pharmacology:Rocaglamide is a potent inhibitor of NFkB in T-lymphocytes with almost complete inhibition at 200nM.1 It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and TNF-α production at 50nM in T-cells without inhibiting AP-1 and NF-kB (conversely, at concentrations <100nM, it was shown to increase NF-kB activity).2 Immunosuppression activity was due to inhibition of cytokine gene expression via blocking of NF-AT activity and is a different mechanism than suppression via Cyclosporine a and FK-506. Rocaglamide has anti-cancer properties via various pathways including ERK inhibition3, ATM/ATR-Chk1/Chk2 activation4, and p38 and JNK activation5.
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