纯度:>98% by HPLC,;NMR (Conforms)
分子式:C24H28O3
分子量:348.49
溶剂:DMSO (4 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Retinoic RAR agonist
Function / Pharmacology:Highly potent and selective retinoic acid analog acting as an RAR agonist (EC50 = 21, 4 and 2.4 nM for RARα, RARβ and RARγ respectively).1 TTNPB has been extensively used in stem cell differentiation protocols. It enhances reprogramming efficiency in chemically induced pluripotent stem cells.2 Chondrocytes are robustly induced from human pluripotent stem cells by treatment with CHIR99021 and TTNPB.3 TTNPB alone, efficiently converts primary adult mouse fibroblasts into dermal papilla cell-like cells.4 Can be used in combination with other small molecules for induction of mouse totipotent stem cells.5