纯度:>98%,;NMR (Conforms)
分子式:C17H12ClF3N2O
分子量:352.74
溶剂:DMSO (>25 mg/ml) Ethanol (10 mg/ml)
性状:Brown solid
存储:-20°C
Activity (short version):Selective COX-1 inhibitor
Function / Pharmacology:SC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.2