纯度:98% by HPLC,;NMR (Conforms)
分子式:C35H35ClNO3S Na
分子量:608.17
溶剂:DMSO (60 mg/ml) Water (30 mg/ml) Ethanol (60 mg/ml)
性状:Solid
存储:-20°C
Activity (short version):Leukotriene CysLT1 antagonist and GPR17 antagonist
Function / Pharmacology:Potent, selective CysLT1 receptor (leukotriene D4) antagonist (Ki = 0.18 nM).1,2 Displays anti-inflammatory and anti-asthmatic effects. Clinically useful agent for treatment of chronic asthma.3 Attenuates chronic brain injury after focal cerebral ischemia in rodent models.4 Decreases blood brain barrier dysfunction in mouse models.5 Blockade of GPR17 by montelukast elevates neural stem and progenitor proliferation.6