纯度:98% by TLC;NMR (Conforms)
分子式:C16H17NO4 ? HCl
分子量:323.77
溶剂:Water (15 mg/ml)
性状:White or off-white solid
存储:RT
Activity (short version):Protein synthesis inhibitor/SCAP degrader
Function / Pharmacology:Arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM4. A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5