纯度:98% by TLC;NMR (Conforms)
分子式:C20H28O6
分子量:364.43
溶剂:DMSO (50 mg/ml) Ethanol (10 mg/ml)
性状:White of off-white solid
存储:-20°C
Activity (short version):HSP70 inhibitor
Function / Pharmacology:A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models.1 Inhibits vascular inflammation in vivo.2 Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling.3 Inhibits migration, invasion and adhesion of melanoma cells.4 Induces apoptosis in osteosarcoma cells by multiple pathways.5