纯度:98% by HPLC,;NMR (Conforms)
分子式:C21H22Cl2FN5O
分子量:450.34
溶剂:DMSO (25 mg/ml) Ethanol (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):c-Met and ALK inhibitor
Function / Pharmacology:A potent and selective inhibitor of c-MET and ALK, IC50s=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negative lymphoma cells.1 Exhibits cytoreductive antitumor efficacy via antiproliferative and antiangiogenic mechanisms.2 Clinically useful anticancer agent.3