纯度:98% by HPLC,;NMR (Conforms)
分子式:C20H24O6
分子量:360.40
溶剂:DMSO (7 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):Immunosupressant
Function / Pharmacology:Possesses potent immunosuppressive and anti-inflammatory activity. Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1 Blocks transactivation of NFκB.2 Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and synergizes with other anticancer agents.3 Inhibits the inflammatory response and remarkably decreases production of TNF-α, IL-1β and IL-6 in a rat model of rheumatoid arthritis.4