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Probucol
- 英文名称:Probucol
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10769
- cas:23288-49-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10769 |
用途 | 科研检测 |
英文名称 | Probucol |
包装规格 | 1MG |
CAS编号 | 23288-49-5 |
别名 | Probucol |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC / TLC;NMR (Conforms)
分子式:C31H48O2S2
分子量:516.84
溶剂:DMSO (100 mg/ml) Ethanol (50 mg/ml)
性状:Off-white solid
存储:RT
Activity (short version):Antioxidant hypercholesterolemic agent
Function / Pharmacology:Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6
分子式:C31H48O2S2
分子量:516.84
溶剂:DMSO (100 mg/ml) Ethanol (50 mg/ml)
性状:Off-white solid
存储:RT
Activity (short version):Antioxidant hypercholesterolemic agent
Function / Pharmacology:Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6