纯度:98% by HPLC / TLC;NMR (Conforms)
分子式:C31H48O2S2
分子量:516.84
溶剂:DMSO (100 mg/ml) Ethanol (50 mg/ml)
性状:Off-white solid
存储:RT
Activity (short version):Antioxidant hypercholesterolemic agent
Function / Pharmacology:Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6