纯度:98% by TLC,;NMR (Conforms)
分子式:C9H12FN3O4
分子量:245.21
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Irreversible DNA methyl transferase inhibitor
Function / Pharmacology:A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation2. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways3. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo4.