纯度:98% by TLC;NMR (Conforms)
分子式:C33H40N2O9
分子量:608.68
溶剂:DMSO (35 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):VMAT1,2 inhibitor
Function / Pharmacology:Indole alkaloid isolated from Rauwolfia serpentina which acts as a potent antihypertensive agent. Irreversibly inhibits both isoforms of vesicular monoamine transporter VMAT1 and 2, Ki=34 and 12 nM, respectively.1,2 May be used to pharmacologically deplete monoamines in various animal models.3 Inhibits the multidrug resistance protein P-glycoprotein, IC50=0.5 mM.3 Reserpine-induced hypokinesia is considered a useful animal model of Parkinson’s disease.5