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PP242
- 英文名称：PP242
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10780
- cas：1092351-67-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10780 |
| 用途 | 科研检测 |
| 英文名称 | PP242 |
| 包装规格 | 1MG |
| CAS编号 | 1092351-67-1 |
| 别名 | PP242 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C16H16N6O
分子量:308.35
溶剂:DMSO (8 mg/ml)
性状:Off-white to beige solid
存储:-20°C
Activity (short version):Dual mTORC1/mTORC2 inhibitor
Function / Pharmacology:PP242 is an ATP-competitive mTORC1/mTORC2 inhibitor (IC50 = 8 nM) displaying high selectivity over PI 3K family kinases (IC50s =0.102 to 2.2 μM) and modest selectivity over PKC family kinases (IC50s =0.049 to 0.198 μM).1,2 PP 242 (but not rapamycin) induced the death of mouse and human leukemia cells but was much weaker than rapamycin at induction of death of normal lymphocytes.3 Restores lysosomal activity and facilitates clearance of amyloid-β in a mouse model of dry age-related macular degeneration.4 Inhibits glioblastoma cell proliferation, migration, invasiveness, and stemness.5
分子式:C16H16N6O
分子量:308.35
溶剂:DMSO (8 mg/ml)
性状:Off-white to beige solid
存储:-20°C
Activity (short version):Dual mTORC1/mTORC2 inhibitor
Function / Pharmacology:PP242 is an ATP-competitive mTORC1/mTORC2 inhibitor (IC50 = 8 nM) displaying high selectivity over PI 3K family kinases (IC50s =0.102 to 2.2 μM) and modest selectivity over PKC family kinases (IC50s =0.049 to 0.198 μM).1,2 PP 242 (but not rapamycin) induced the death of mouse and human leukemia cells but was much weaker than rapamycin at induction of death of normal lymphocytes.3 Restores lysosomal activity and facilitates clearance of amyloid-β in a mouse model of dry age-related macular degeneration.4 Inhibits glioblastoma cell proliferation, migration, invasiveness, and stemness.5
