纯度:98% by TLC;NMR (Conforms)
分子式:C18H18N2O4
分子量:326.35
溶剂:DMSO (4 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):HDAC inhibitor
Function / Pharmacology:Inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 ?M) and HDAC8 (IC50~1 ?M) and is less toxic compared to trichostatin A.1,2 Induces cell cycle arrest and epigenetic changes in colon cancer cells.3 Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic cell nuclear transfer (SCNT) embryos.4 Increases exercise endurance in mice.5