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NSC23766
- 英文名称：NSC23766
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10789
- cas：733767-34-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10789 |
| 用途 | 科研检测 |
| 英文名称 | NSC23766 |
| 包装规格 | 1MG |
| CAS编号 | 733767-34-5 |
| 别名 | NSC23766 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C24H35N7 · 3HCl
分子量:530.98
溶剂:DMSO (50 mg/ml) Water (50 mg/ml)
性状:White solid
存储:RT
Activity (short version):Rac1 GTPase inhibitor
Function / Pharmacology:NSC-23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.
分子式:C24H35N7 · 3HCl
分子量:530.98
溶剂:DMSO (50 mg/ml) Water (50 mg/ml)
性状:White solid
存储:RT
Activity (short version):Rac1 GTPase inhibitor
Function / Pharmacology:NSC-23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.
