纯度:>99% by HPLC,;NMR (Conforms)
分子式:C6H6N2O
分子量:122.13
溶剂:DMSO (50 mg/ml); water (50 ml)
性状:White solid
存储:RT
Activity (short version):SIRT1 inhibitor/essential nutrient
Function / Pharmacology:Essential nutrient (amide form of Vitamin B3) that is incorporated into cofactors NADH/NAD+, important for ATP production and other key metabolic functions.1 Transiently inhibits SIRT1/SIRT3 through feedback inhibition (IC50 ~ 50 μM)2, but is quickly converted to NAD+ in cells3. Also inhibits certain kinases (e.g. ROCK and CK1), making it a regulator of hPSC pluripotency, survival, and differentiation.4 Inhibits differentiation and enhances functionality of hematopoietic stem/progenitor cells (HSPCs).5