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Purvalanol A
- 英文名称：Purvalanol A
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10834
- cas：212844-53-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10834 |
| 用途 | 科研检测 |
| 英文名称 | Purvalanol A |
| 包装规格 | 1MG |
| CAS编号 | 212844-53-6 |
| 别名 | Purvalanol A |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC,;NMR (Conforms)
分子式:C19H25ClN6O
分子量:388.89
溶剂:DMSO (35 mg/ml)
性状:Pale green solid
存储:-20°C
Activity (short version):CDK inhibitor
Function / Pharmacology:Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.
分子式:C19H25ClN6O
分子量:388.89
溶剂:DMSO (35 mg/ml)
性状:Pale green solid
存储:-20°C
Activity (short version):CDK inhibitor
Function / Pharmacology:Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.
