纯度:98% by HPLC;NMR (Conforms)
分子式:C17H25N3O2
分子量:303.40
溶剂:DMSO (45 mg/ml) DMF (20 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):DPP4 inhibitor
Function / Pharmacology:A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1)1. Delaying the degradation of GLP-1 extends the action of insulin and suppressing the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia)2. Clinically useful antidiabetic agent. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model3. Displays protective effects on β-cells by inhibition of ER stress in a mouse model4.