纯度:>98% HPLC, NMR (Conforms)
分子式:C27H32ClN5O5
分子量:542.03
溶剂:DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
性状:White solid
存储:-20°C
Activity (short version):Src family kinase inhibitor
Function / Pharmacology:Potent and selective inhibitor of Src family kinases, IC50=4-10 nM for Src, c-Yes, Fyn, Lyn, Blk, Fgr and Lck.1 Demonstrates potent antimigratory, anti-invasive and antiproliferative activity and inhibits metastasis in a mouse model of bladder cancer.2 Inhibits MERS- CoV at early stages of the viral life cycle at mM concentrations.3,4 Rescues memory performance and reduces phospho-Tau accumulation in traumatic tauopathy.5 Rescues memory deficits and synaptic depletion in an Alzheimer’s mouse model.6