纯度:>98% by TLC,;NMR (Conforms)
分子式:C30H41FN4O12
分子量:668.67
溶剂:DMSO (20 mg/ml)
性状:Lyophilized solid
存储:-20°C
Activity (short version):Caspase3 inhibitor (cell permeable)
Function / Pharmacology:Z-DEVD-FMK (210344-95-9) is a cell-permeable trimethyl ester form of the irreversible caspase-3 inhibitor DEVD-FMK (fluoromethylketone) with IC50 = 130 nM.1,2 Methyl esters confer cell permeability and are hydrolyzed to the active COOH form via intracellular esterases. Inhibits caspase-3-dependent apoptosis and pyroptosis in a variety of cell lines.3,4 Active in vivo.5