纯度:98% by TLC,;NMR (Conforms)
分子式:C15H13NO2
分子量:239.27
溶剂:DMSO (25 mg/ml) Ethanol (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Estrogen ERβ agonist
Function / Pharmacology:Potent estrogen ERβ receptor agonist. Displays a 70-fold selectivity over ERα, EC50 = 0.85 and 66 nM, respectively.1 Regulates expression of GluR1, 2 and 3 in rat hippocampus.2 Ameliorates portal hypertension in a carbon tetrachloride-induced liver cirrhosis rat model.3 Stimulates proliferation of androgen-independent prostate cancer cell line PC-3 via a novel pathway involving ERβ-mediated activation of β-catenin.4 A useful tool for elucidating the biological function of ERβ.5