纯度:98% by HPLC;NMR (Conforms)
分子式:C17H19FN2O2
分子量:302.34
溶剂:DMSO (50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):MAO-B inhibitor, Parkinson's therapeutic
Function / Pharmacology:A selective and reversible inhibitor of monoamine oxidase B (MAO-B, IC50=98 nM with greater than 100-fold selectivity over MAO-A.1 Displays anticonvulsant activity2 and protects against kainate-induced seizures and hippocampal neurodegeneration in rat models3. Reduces overactive glutamatergic signaling via use-dependent sodium channel blockade.4 A novel therapeutic for Parkinson’s disease with multiple modes of action.5 Effective as an add-on to dopamine agonist therapy in early Parkinson’s.6