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PLX-4032
- 英文名称:PLX-4032
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10847
- cas:918504-65-1
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10847 |
用途 | 科研检测 |
英文名称 | PLX-4032 |
包装规格 | 1MG |
CAS编号 | 918504-65-1 |
别名 | PLX-4032 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:99% by HPLC,;NMR (Conforms)
分子式:C23H18ClF2N3O3S
分子量:489.92
溶剂:DMSO (100 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):BRAF inhibitor
Function / Pharmacology:An ATP-competitive inhibitor of mutant V600E/F and wild type B-Raf, IC50s=31 and 100 nM respectively.1 Induced growth inhibition, G0/G1 arrest and apoptosis in a variety of cancer cell lines, with a B-Raf mutation favoring but not guaranteeing a response.2 Inhibits the growth of B-Raf V600E-positive melanomas in vitro and in vivo.3 Treatment of patients that carry the V600E BRAF mutation resulted in complete or partial tumor regression.4
分子式:C23H18ClF2N3O3S
分子量:489.92
溶剂:DMSO (100 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):BRAF inhibitor
Function / Pharmacology:An ATP-competitive inhibitor of mutant V600E/F and wild type B-Raf, IC50s=31 and 100 nM respectively.1 Induced growth inhibition, G0/G1 arrest and apoptosis in a variety of cancer cell lines, with a B-Raf mutation favoring but not guaranteeing a response.2 Inhibits the growth of B-Raf V600E-positive melanomas in vitro and in vivo.3 Treatment of patients that carry the V600E BRAF mutation resulted in complete or partial tumor regression.4