纯度:98% by TLC;NMR (Conforms)
分子式:C15H9F6N5OS
分子量:421.32
溶剂:DMSO (40 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):CRAC channel blocker
Function / Pharmacology:YM-58483 is a CRAC (calcium release-activated calcium) channel blocker1, a prototypic store-operated calcium channel2. Inhibits antigen-induced histamine release via modulation of mast cell responses.3 Displays potent analgesic actions in various pain models in mice and is orally active.4 Inhibits T cell-mediated immune responses in vivo.5