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SB-525334
- 英文名称：SB-525334
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10861
- cas：356559-20-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10861 |
| 用途 | 科研检测 |
| 英文名称 | SB-525334 |
| 包装规格 | 1MG |
| CAS编号 | 356559-20-1 |
| 别名 | SB-525334 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C21H21N5
分子量:343.42
溶剂:DMSO (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):ALK5 (TGFβR1) inhibitor
Function / Pharmacology:Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.
分子式:C21H21N5
分子量:343.42
溶剂:DMSO (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):ALK5 (TGFβR1) inhibitor
Function / Pharmacology:Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.
