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SB-525334
- 英文名称:SB-525334
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10861
- cas:356559-20-1
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10861 |
用途 | 科研检测 |
英文名称 | SB-525334 |
包装规格 | 1MG |
CAS编号 | 356559-20-1 |
别名 | SB-525334 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C21H21N5
分子量:343.42
溶剂:DMSO (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):ALK5 (TGFβR1) inhibitor
Function / Pharmacology:Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.
分子式:C21H21N5
分子量:343.42
溶剂:DMSO (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):ALK5 (TGFβR1) inhibitor
Function / Pharmacology:Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.