纯度:98% by HPLC;NMR (Conforms)
分子式:C20H23N2O5S ? Na
分子量:426.46
溶剂:DMSO (40 mg/ml) Water (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):NLRP3 inflammasome inhibitor
Function / Pharmacology:MCC-950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-11. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes2. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)3. Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome4. A valuable new tool for exploring the pathophysiology of NLRP3.