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CX-5461
- 英文名称:CX-5461
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10864
- cas:1138549-36-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10864 |
用途 | 科研检测 |
英文名称 | CX-5461 |
包装规格 | 1MG |
CAS编号 | 1138549-36-6 |
别名 | CX-5461 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC,;NMR (Conforms)
分子式:C27H27N7O2S
分子量:513.62
溶剂:DMSO (10 mg/ml with warming)
性状:Off-white solid
存储:RT
Activity (short version):RNA polymerase I inhibitor
Function / Pharmacology:CX-5461 (1138549-36-6) is a first-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II.1,2 Activates the DNA damage response.3 It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING.4 Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant.5
分子式:C27H27N7O2S
分子量:513.62
溶剂:DMSO (10 mg/ml with warming)
性状:Off-white solid
存储:RT
Activity (short version):RNA polymerase I inhibitor
Function / Pharmacology:CX-5461 (1138549-36-6) is a first-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II.1,2 Activates the DNA damage response.3 It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING.4 Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant.5