纯度:98% by TLC;NMR (Conforms)
分子式:C29H40N2O4 ? 2HCl (XH2O)
分子量:553.56
溶剂:Water (100 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Protein synthesis inhibitor
Function / Pharmacology:One of the active ingredients of ipecac root extract, used as an emetic.1 Induces apoptosis in breast cancer cells via inhibition of Wnt/?-catenin signaling.2 Inhibits Zika and Ebola virus in vitro and in vivo, targeting viral entry and replication by inhibiting viral RNA polymerase and host lysosomal function.3 Also inhibits SARS-CoV-2 replication in cells (EC50 for viral load reduction is 0.46 ?M).4 A useful agent for inhibiting protein synthesis in eukaryotic cells by virtue of its inhibition of the ribosome 40S subunit.5