纯度:98% by HPLC;NMR (Conforms)
分子式:C22H26N2O4
分子量:382.45
溶剂:DMSO (75 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Calpain inhibitor
Function / Pharmacology:A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 μM in intact cell assay.4