![]() |
MDL-28170
- 英文名称:MDL-28170
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10866
- cas:88191-84-8
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10866 |
用途 | 科研检测 |
英文名称 | MDL-28170 |
包装规格 | 1MG |
CAS编号 | 88191-84-8 |
别名 | MDL-28170 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C22H26N2O4
分子量:382.45
溶剂:DMSO (75 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Calpain inhibitor
Function / Pharmacology:A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 μM in intact cell assay.4
分子式:C22H26N2O4
分子量:382.45
溶剂:DMSO (75 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Calpain inhibitor
Function / Pharmacology:A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 μM in intact cell assay.4