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Homoharringtonine
  • 英文名称:Homoharringtonine
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10874
  • cas:26833-87-4
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10874
用途 科研检测
英文名称 Homoharringtonine
包装规格 1MG
CAS编号 26833-87-4
别名 Homoharringtonine
纯度 98+%
分子式
是否进口
纯度:95% by HPLC;NMR (Conforms)
分子式:C29H39NO9
分子量:545.63
溶剂:DMSO (75 mg/ml)
性状:Pale yellow to off-white solid
存储:-20°C
Activity (short version):Protein synthesis inhibitor
Function / Pharmacology:A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
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