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Homoharringtonine
- 英文名称:Homoharringtonine
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10874
- cas:26833-87-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10874 |
用途 | 科研检测 |
英文名称 | Homoharringtonine |
包装规格 | 1MG |
CAS编号 | 26833-87-4 |
别名 | Homoharringtonine |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:95% by HPLC;NMR (Conforms)
分子式:C29H39NO9
分子量:545.63
溶剂:DMSO (75 mg/ml)
性状:Pale yellow to off-white solid
存储:-20°C
Activity (short version):Protein synthesis inhibitor
Function / Pharmacology:A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
分子式:C29H39NO9
分子量:545.63
溶剂:DMSO (75 mg/ml)
性状:Pale yellow to off-white solid
存储:-20°C
Activity (short version):Protein synthesis inhibitor
Function / Pharmacology:A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.