纯度:98% by TLC,;NMR (Conforms)
分子式:C19H19N3O6
分子量:385.38
溶剂:DMSO (25 mg/ml) Ethanol (15 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Syk inhibitor and Ca channel blocker
Function / Pharmacology:A novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model.1 Clinically useful antihypertensive agent.2 Has been shown to prevent cognitive decline in some clinical trials.3 Produces a protective effect on glutamate neurotoxicity in retinal ganglion cells, an effect not shared by other L-type Ca2+ channel blockers such as nifedipine and diltiazem.4