纯度:98% by TLC,;NMR (Conforms)
分子式:C14H11NO5
分子量:273.24
溶剂:DMSO (25 mg/ml) Ethanol (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):COMT inhibitor; TTR aggregation inhibitor
Function / Pharmacology:Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity.2 Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo.3 Inhibits O-methylation of exogenous polyphenols such as EGCG.4 Cell permeable. Orally bioavailable