纯度:98% by TLC,;NMR (Conforms)
分子式:C26H26N2O5
分子量:446.50
溶剂:DMSO (30 mg/ml) Ethanol (50 mg/ml)
性状:Off-white to pale yellow solid
存储:-20°C
Activity (short version):Cathepsin L inhibitor
Function / Pharmacology:A potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2