纯度:98% by TLC,;NMR (Conforms)
分子式:C19H19N5O
分子量:333.39
溶剂:DMSO (25 mg/ml) Ethanol (10 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):Arylhydrocarbon receptor antagonist
Function / Pharmacology:Arylhydrocarbon (AhR) receptor antagonist, IC50=30 nM.1 Blocks endogenous AhR agonist-induced differentiation of Th17 cells.2 Promotes expansion of human hematopoietic stem cells.3 Mitigates cytokine-mediated inflammatory signaling in human fibroblast-like synoviocytes.4 An important tool for probing the involvement of AhR in the toxicity of various environmental toxins such as TCDD and other dioxins.5